George Clooney was born on May 6, 1961, in Lexington, Kentucky, to Nina Bruce, a former beauty pageant queen, and Nick Clooney, a former anchorman and television host. His first major role was on the sitcom "E/R" (1984) as Ace. More roles soon followed, including George Burnett, the handsome handyman on "The Facts of Life" (1979); Booker Brooks, a supervisor on "Roseanne" (1988); and Detective James Falconer on "Sisters" (1991). Clooney had his breakthrough when he was cast as Dr. Doug Ross on the award-winning drama series ER (1994), opposite Anthony Edwards, Noah Wyle, and Julianna Margulies.

Source: IMDb